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Faculty of Chemistry

 

Welcome to the Faculty of Chemistry

In order take the sustainability and environmental compatibility into account the research foci in chemistry have changed during the last years. The enormous importance of chemistry in economy, i.e. energy supply, development of new materials, pharmaceutical research and biotechnology, is unambiguous. The close collaboration of the Faculty of Chemistry with natural scientists and engineers of the University Stuttgart, as well as with scientists of the local Max-Planck-, Fraunhofer-, and Textile Chemistry and Chemical Fibers Institute, provides a considerable location advantage.

New Publications

Together against germs

The Ministry of Science, Research and the Arts of the State of Baden-Württemberg (MWK) supports a new transregional and interdisciplinary research group “antibioPPAP” that aims to develop polycyclic polyprenylated acylphloroglucines (PPAP) as novel antibiotics agains multiresistent enterococci (MRE). Speakers of the consortium are Prof. Friedrich Götz, Interfakultäres Institut für Mikrobiologie und Infektionsmedizin, Tübingen University, and Prof. Bernd Plietker, Institut für Organische Chemie, Stuttgart University. Recently, both groups were able to show that PPAPs are novel non-peptide based antibiotics that show promising activities against MRSA and VRE albeit with moderate to low cytotoxicity. Within the research group scientists of the faculties of chemistry, Stuttgart university, biology, Tübingen university, and university hospital of Ulm are cooperating to optimize the structure-activity relationship, to decrease the toxicity, to improve the pharmacokinetics, and to identify the mode-of-action. The overarching goal is to build a profound knowledge base for PPAP-based antibiotics that pave the way toward clinical studies.
*)original publication: Polycyclic Polyprenylated Acylphloroglucinols: An Emerging Class of Non-Peptide-Based MRSA- and VRE-Active Antibiotics, by Claudia Guttroff, Aslihan Baykal, HuanhuanWang, Peter Popella, Frank Kraus, Nicole Biber, Sophia Krauss, Friedrich Götz und Bernd Plietker, Angew Chem Int Ed Engl. 2017, 56,15852-15856. doi: 10.1002/anie.201707069
Contact:
Prof. Dr. Friedrich Götz (friedrich.goetz(at)uni-tuebingen.de)
and Prof. Dr. Bernd Plietker
E-Mail

Publication in Angewandte Chemie: Lord of The Crowns: A New Precious In The Kingdom of Clustomesogens

Clustomesogens are liquid crystalline hybrid materials containing anisometric transition metal cluster compounds. This class of nanomaterials discovered in Rennes in 2010 is now an integral part of liquid crystal nanoscience. In this work published in Angewandte Chemie on July 10th, alcali salts (K or Cs) of luminescent cluster compounds were synthesized by high temperature solid state chemistry and combined to crown-shaped organic discotic liquid crystals containing a 15C5 crown ether complexing center and flat aromatic peripheral units. The resulting hybrids are homogeneous and stable up to high temperature despite the weakness of the supramolecular interactions binding both components. All hybrids show hexagonal columnar arrangements and strong Red‐NIR emission. Surprisingly, when chlorinated clusters are used instead of brominated ones, the mesophase stability is largely enhanced. This work results from a fruitful collaboration partly financed by a DAAD-PHC Procope bilateral project between the University of Stuttgart (Department of organic chemistry, team of Prof. Sabine Laschat) and the University of Rennes (Institut des Sciences Chimiques de Rennes, Prof. Yann Molard and team CSM).
by Kevin Guy, Philipp Ehni, Serge Paofai, Claire Roiland, Maria Amela-Cortes, Stéphane Cordier, Sabine Laschat and Yann Molard

Angew. Chem. Int. Ed. 2018,
DOI: 10.1002/anie.201806556

For further information please contact
Yann Molard, Institut des Sciences Chimiques de Rennes, yann.molard(at)univ-rennes1.fr
and Sabine Laschat

Institut für Organische Chemie
Universität Stuttgart
E-Mail
Financial support: PHC Procope “PLISE” n° 37689XA & ANR Clustomesogen ANR-13-BS07-0003-01

Publication in Angewandte Chemie Int. Ed.: Double Regioselective Asymmetric C-Allylation of Isoxazolinones: Iridium Catalyzed N-Allylation Followed by an Aza-Cope-Rearrangement

Isoxazolinones are pharmacologically interesting densely functionalized heterocycles, which are usually difficult to produce in enantioenriched form by means of asymmetric catalysis. Moreover, the functionalization of isoxazolinones often suffers from a lack of regioselectivity. The Peters group has now reported the first enantioselective C-allylations of isoxazolinones. They proceeded with high regioselectivity favoring the linear allylation products, although Ir phosphoramidite catalysts were employed, which normally result in branched regioisomers in allylic substitutions. This investigation shows that the new reaction involves a cascade of steps including an initial regio- and enantioselective N-allylation giving a branched allyl intermediate, followed by a spontaneous [3,3]-rearrangement, which allows for a translocation of chirality.
by S. Rieckhoff, J. Meisner, J. Kästner, W. Frey, R. Peters

Angew. Chem. Int. Ed. 2018, 57, 1404–1408
https://doi.org/10.1063/1.5018928

For further information please contact
Prof. Dr. René Peters
Institute of Organic Chemistry
University of Stuttgart
E-Mail

Editor's Choice: Publication in Journal of Chemical Physics: Refined analysis of the X̃ 2 A2←X̃ 1 A1 photoelectron spectrum of furan


by Taras Petrenko and Guntram Rauhut

J. Chem. Phys. 148, 054306, 2018
https://doi.org/10.1063/1.5018928

For further information please contact
Prof. Dr. Guntram Rauhut
Institute of Theoretical Chemistry
University of Stuttgart
E-Mail

Publication in Advanced Functional Materials: Macroscopic Properties of Biomimetic Ceramics Are Governed by the Molecular Recognition at the Bioorganic–Inorganic Interface


by Stefan Kilper, Sandra J. Facey, Zaklina Burghard, Bernhard Hauer, Dirk Rothenstein,* and Joachim Bill

Adv. Funct. Mat. 2018
DOI: 10.1002/adfm.201705842

For further information please contact
Dr. Dirk Rothenstein
Institute of Material Science
University of Stuttgart
E-Mail

Publication in Angewandte Chemie Int. Ed.: Polycyclic polyprenylated acylphloroglucinols – an emerging class of non-peptide-based MRSA- and VRE-active antibiotics

Globally, an increasing number of germs are being registered that are avoiding treatment with available antibiotics. For this reason, the WHO has prioritized the development of new antibiotics against methicilin-resistant Stapyhlococcus aureus (MRSA). The currently common reserve antibiotics are often peptide-based (e.g., vancomycin, teicoplanin, etc.) and inhibit i.a. cell wall biosynthesis of Gram-positive bacteria. However, the number of reports of vancomycin-resistant Staphylococcus aureus strains (VRSA) is also increasing here. A team of immunologists from the University of Tübingen and chemists at the University of Stuttgart have now succeeded in developing endo-type B PPAPs as a new class of non-peptide-based MRSA and VRSA-active antibiotics. The most active compounds are active against multidrug-resistant Staphylococcus aureus and various vancomycin-resistant Enterococci. Four new structures have been identified, demonstrating that the PPAP backbone could become a new non-peptide-based lead in antibiotic research characterized by the combination of high activity and low cytotoxicity.
by Claudia Guttroff, Aslihan Baykal, HuanhuanWang, Peter Popella, Frank Kraus, Nicole Biber, Sophia Krauss, Friedrich Götz und Bernd Plietker*

Angew. Chemie Int. Ed. 56, 2017
DOI:10.1002/ange.201707069

For further information please contact
Prof. Bernd Plietker
Institute of Organic Chemistry
University of Stuttgart
E-Mail

Publication in Chemistry - A European Journal (inclusive Frontispiece): Copper photosensitizers containing P^N ligands and their influence on photoactivity and stability.

Conventional diphosphine P^P ligands were replaced by a heterobidentate P^N ligand in order to enhance stability and absorptivity of the resulting copper photosensitizers. A combined photophysical, electrochemical and theoretical study gives insights into structure-activity-relationships and explains the photocatalytic activity.
by R. Giereth, W. Frey, H. Junge, S. Tschierlei* and M. Karnahl*

Chem. Eur. J., 2017, inclusive Frontispiece
DOI: 10.1002/chem.201703672

For further information please contact
Dr. Michael Karnahl
Institute of Organic Chemistry
University of Stuttgart
E-Mail

Publication in Nature Communications: Modular fluorescence complementation sensors for live cell detection of epigenetic signals at endogenous genomic sites

by Cristiana Lungu, Sabine Pinter, Julian Broche, Philipp Rathert and Albert Jeltsch

Nature Commun. 8, 649, 2017
DOI: 10.1038/s41467-017-00457-z

For further information please contact
Prof. Albert Jeltsch
Institute of Biochemistry and Technical Biochemistry
University of Stuttgart
E-Mail

Hot paper in Chem. Eur. J.: A N-heterocyclic Phosphenium Complex of Manganese: Synthesis and Catalytic Activity in Ammonia-Borane Dehydrogenation


by M. Gediga, C. M. Feil, S. H. Schlindwein, J. Bender, M. Nieger, and D. Gudat

Chem. Eur. J. 23 (48), 11560, 2017
DOI: 10.1002/chem.201701442

For further information please contact
Prof. Dietrich Gudat
Institute of Inorganic Chemistry
University of Stuttgart
E-Mail

Publication in Angewandte Chemie Int. Ed.: Iron-Catalyzed Intramolecular Aminations of C(sp3)−H Bonds in Alkylaryl Azides

Nitrogen-containing heterocycles are important structural motifs in various natural product, but they are privileged structures in medicinal chemistry and (increasingly) material science (organic electronics). A novel, efficient method for the preparation of indolines via direct amination of unactivated C(sp3)-H-bonds using an iron-catalyst was now developed in the Institute of Organic chemistry. Densely functionalized, complex structures are accessible within just one synthetic operation.
by Isabel Alt, Claudia Guttroff and Bernd Plietker

Angew. Chemie Int. Ed. 55 (35), 10582, 2017
DOI:10.1002/anie.201704260

For further information please contact
Prof. Bernd Plietker
Institute of Organic Chemistry
University of Stuttgart
E-Mail

Highlights - Press release: Creating Honeycomb Structures in Porous Polymers by Osmotic Transport



Advances in Engineering

For further information please contact
Prof. Cosima Stubenrauch
Institute of Physical Chemistry
University of Stuttgart
E-Mail

Publication in Nature Communications: Design of synthetic epigenetic circuits featuring memory effects and reversible switching based on DNA methylation


by Johannes A. H. Maier, Raphael Möhrle and Albert Jeltsch

Nature Comm. 8, 15336, 2017 2017

For further information please contact
Prof. Albert Jeltsch
Institut of Biochemistry
University Stuttgart
E-Mail

Publication in Angewandte Chemie Int. Ed.: High-Pressure NiAs-Type Modification of FeN


by William P. Clark, Simon Steinberg, Richard Dronskowski, Catherine McCammon, Ilya Kupenko, Maxim Bykov, Leonid Dubrovinsky, Lev G. Akselrud, Ulrich Schwarz and Rainer Niewa

Angew. Chemie Int. Ed. 2017

For further information please contact
Prof. Rainer Niewa
Institute of Inorganic Chemistry
University of Stuttgart
E-Mail

Review in Angewandte Chemie Int. Ed.: Chemical and Biological Aspects of Nutritional Immunity - Perspectives for New Anti-infectives Targeting Iron Uptake Systems


by Sabine Laschat, Ursula Bilitewski, Joshua Blodgett, Anne- Kathrin Duhme-Klair, Sabrina Dallavalle, Anne Routledge, and Rainer Schobert
Angew. Chemie Int. Ed. 2017
DOI: 10.1002/anie.201701586

For further information please contact
Prof. Sabine Laschat
Institute of Organic Chemistry
University of Stuttgart
E-Mail