Bioinspired Mineralisation

Fig 1: Bioinspired ZnO mineralization
according to the Ostwald Rule of Stages.
Fig. 2: Particle growth of ZnO
in the presence of gelatine.

By applying bioinspired mineralization synthesis routes, various oxide ceramics like zinc oxide (ZnO), titania (TiO2), or zirconia (ZrO2) can be generated under moderate reaction conditions. These materials display favorable electrical and optical properties. The mineralization process can be controlled by the addition of bio-organic additives (e.g. peptides, proteins).

Recently, we showed that the bioinspired mineralization of ZnO in the presence of ZnO-binding peptides has metastable layered basic zinc salts (LBZs) intermediate stages before ZnO is finally obtained (Fig. 1). Thereby, the bioinspired mineralization of ZnO follows the Ostwald rule of stages. The morphology of the mineralized ZnO is modified by the selective adsorption of the peptides to the inorganic material. By analogy with proteins like gelatine, lysozyme, or bovine serum albumin, the ZnO particle growth can be modulated (Fig. 2). Thereby, the activation energy (EA) is drastically decreased by the presence of the protein. The EA lowering is attained by the attractive electrostatic interactions between organic and inorganic components.



DFG PAK 410: Biologische Erzeugung von Oxidkeramiken
In vitro und in vivo Synthesen von Oxidkeramiken

Baden-Württemberg Stiftung Kompetenznetz Funktionelle Nanostrukturen
Selbstwachsende Elektronik durch bioinspirierte Mineralisierung -  Templatkontrolliert mit Auflösung im Nanometerbereich


Baier, J., Blumenstein, N.J., Preusker, J., Jeurgens, L.P.H., Welzel, U., Do, T.A., Pleiss, J., Bill, J., 2014. The influence of ZnO-binding 12-mer peptides on bio-inspired ZnO formation. CrystEngComm 16, 5301-5307.

Eisele, R., Blumenstein, N.J., Baier, J., Walheim, S., Schimmel, T., Bill, J., 2014. Synthesis and characterization of textured Al-doped zinc oxide films prepared by template-directed deposition. CrystEngComm 16, 1560-1567.

Baier, J., Naumburg, T., Blumenstein, N.J., Jeurgens, L.P.H., Welzel, U., Do, T.A., Pleiss, J., Bill, J., 2012. Bio-inspired mineralization of zinc oxide in presence of ZnO-binding peptides. Biointerface research in applied chemistry 2, 380-391.

Baier, J., Strumberger, R., Berger, F., Atanasova, P., Welzel, U., Bill, J., 2012. Mineralization and particle growth kinetics of ZnO in the presence of gelatine. Biointerface research in applied chemistry 2, 339-349

Durupthy, O., Jeurgens, L.P., Bill, J., 2011. Biomimetic formation of Titania Thin Films: Effect of Amino Acids on the Deposition Process. ACS Appl Mater Interfaces.

Santhiya, D., Burghard, Z., Greiner, C., Jeurgens, L.P.H., Subkowski, T., Bill, J., 2010. Bioinspired Deposition of TiO2 Thin Films Induced by Hydrophobins. Langmuir 26, 6494-6502.

Bauermann, L.P., Bill, J., Aldinger, F., 2007. Bio-inspired syntheses of ZnO-protein composites. International Journal of Materials Research 98, 879-883.

Durupthy, O., Bill, J., Aldinger, F., 2007. Bioinspired synthesis of crystalline TiO2: Effect of amino acids on nanoparticles structure and shape. Crystal Growth & Design 7, 2696-2704.

Bauermann, L.P., Bill, J., Aldinger, F., 2006. Bio-friendly synthesis of ZnO nanoparticles in aqueous solution at near-neutral pH and low temperature. The journal of physical chemistry 110, 5182-5185.

Bauermann, L.P., del Campo, A., Bill, J., Aldinger, F., 2006. Heterogeneous nucleation of ZnO using gelatin as the organic matrix. Chemistry of Materials 18, 2016-2020.

Bill, J., 2006. Bio-inspired processing of ceramic materials, 11th International Ceramics Congress, CIMTEC 2006, Acireale, Sicily, Italy, p. 643.

Gerstel, P., Hoffmann, R.C., Lipowsky, P., Jeurgens, L.P.H., Bill, J., Aldinger, F., 2006. Mineralization from aqueous solutions of zinc salts directed by amino acids and peptides. Chemistry of Materials 18, 179-186.

Gerstel, P., Lipowsky, P., Durupthy, O., Hoffmann, R.C., Bellina, P., Bill, J., Aldinger, F., 2006. Deposition of zinc oxide and layered basic zinc salts from aqueous solutions containing amino acids and dipeptides. Journal of the Ceramic Society of Japan 114, 911-917.

Bill, J., Gerstel, P., Hoffmann, R.C., Jeurgens, L.P.H., Lipowsky, P., Wildhack, S., Aldinger, F., 2005. Bio-inspired evolution of zinc oxide-based materials directed by amino acids and peptides, in: Sandhage, K.H., Yang, S., Douglas, T., Parker, A.R., DiMasi, E. (Eds.), Mater. Res. Soc. Symp.: Biological and Bio-Inspired Materials and Devices (873E), Warrendale, PA, USA, p. K5.3.

Bill, J., Hoffmann, R., Fuchs, T., Aldinger, F., 2003. Template-induced deposition of ceramic materials from aqueous solution, in: Sōmiya, S. (Ed.), Handbook of Advanced Ceramics. Academic Press, Burlington, MA, USA, pp. 391-420.

Bill, J., Hoffmann, R.C., Fuchs, T.M., Aldinger, F., 2002. Deposition of ceramic materials from aqueous solution induced by organic templates. Zeitschrift Fur Metallkunde 93, 478-489.