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Institut für Organische Chemie
The macrolide antibiotic borrelidine is an interesting target compound for several research groups due to its unique structure and its versatile biological activity. [1,2] The natural product was first isolated from Streptomyces rochei in 1949 by Berger et al. as an antibiotic possessing anti-borrelia activity. Its biological activity includes, but is not limited to, the selective inhibition of threonyl tRNA synthetase, antiviral as well as antiangiogenesis activities. In order to gain a better understanding of the researching for viable synthetic routes to borrelidine and its analogues and testing them in several cell lines.
 Review: Nagamitsu T., Harigaya Y. Omura S., Proc. Japan Acad Ser. B 2005, 81, 244-256.
 Theurer M., El Bay Y., Koschorreck K., Urlacher Vlada B., Rauhut G., Baro A., and Laschat S. Eur. J. Org. Chem. 2011, 4241-4249.