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Prof. Dr. Laschat
Universität Stuttgart
Pfaffenwaldring 55
D-70569 Stuttgart

Sec. 
Ursula Henn
NWZ I, 5-102
+49711 685 64268
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Gündemir, Tülay

Frau 
Tülay Gündemir-Durmaz
PhD. Student

Dieses Bild zeigt  Tülay Gündemir-Durmaz
Telefon 0049 711 685-64277
Raum5.361
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Universität Stuttgart
Institut für Organische Chemie
Pfaffenwaldring 55
70569 Stuttgart
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Fachgebiet:

Natural products

The macrolide antibiotic borrelidine is an interesting target compound for several research groups due to its unique structure and its versatile biological activity. [1,2] The natural product was first isolated from Streptomyces rochei in 1949 by Berger et al. as an antibiotic possessing anti-borrelia activity. Its biological activity includes, but is not limited to, the selective inhibition of threonyl tRNA synthetase, antiviral as well as antiangiogenesis activities. In order to gain a better understanding of the researching for viable synthetic routes to borrelidine and its analogues and testing them in several cell lines.

Borrelidine

References

[1]   Review: Nagamitsu T., Harigaya Y. Omura S., Proc. Japan Acad Ser. B 2005, 81, 244-256.

[2]   Theurer M., El Bay Y., Koschorreck K., Urlacher Vlada B., Rauhut G., Baro A., and Laschat S. Eur. J. Org. Chem. 2011, 4241-4249.