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Lehrstuhl für Makromolekulare Stoffe und Faserchemie |
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Prof. Dr. Michael R. Buchmeiser |
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Porous polymeric monolithic materials are prepared via ring-opening metathesis polymerization from suitable
norborn-2-ene- and a 7-oxanorborn-2-ene-based cross-linkers in the presence of porogenic solvents (i.e., 2-propanol and
toluene) and norborn-2-enephosphonate surface-modified nanoparticles (e.g., CaCO3, hdroxyapatite). The experimental setup
and the conditions chosen allowed for the manufacturing of polymeric monoliths characterized by a homogeneous distribution
of the inorganic nanoparticles throughout the polymeric monolith. Depending on the nanoparticle content, the macropore
diameters can be varied in the 30-400 mm regime. The thus prepared scaffolds are then seeded with mesenchymal stem cells
and subjected to either osseous or adipogenic cell differentiation. Current research focuses on the surface-immobilization
of the supports with suitable messenger molecules that allow for tailoring both cell adhesion and differentiation.
In-vitro and in-vivo cell experiments are carried out by our medical partners. References: 1) Monolithic Polymers for Cell Cultivation, Differentiation, and Tissue Engineering, A. Löber, A. Verch, B. Schlemmer, B. Frerich, M. R. Buchmeiser, Angew. Chem., 120, 9279-9281 (2008); Angew. Chem. Int. Ed. 47 9138-9141 (2008) 2) ROMP-Derived cyclooctene-based monolithic polymeric materials reinforced with inorganic nanoparticles for applications in tissue engineering, F. Weichelt, S. Lenz, S. Tiede, I. Reinhardt, B. Frerich, M. R. Buchmeiser, Beilstein J. Org. Chem., 6, 1199–1205 (2010) 3) Polymers in Biomedicine and Electronics, A. Lendlein, M. Rehahn, M. R. Buchmeiser, R. Haag, Macromol. Rapid Commun. 31, 1487–1491 (2010) 4) Ring-Opening Metathesis Polymerization-Based Synthesis of CaCO3 Nanoparticle-Reinforced Polymeric Monoliths for Tissue Engineering, F. Weichelt, B. Frerich, S. Lenz, S. Tiede, M. R. Buchmeiser, Macromol. Rapid Commun., 31, 1540-1545 (2010) 5) Monolithic Biocompatible and Biodegradable Scaffolds for Tissue Engineering, M. R. Buchmeiser, J. Polym. Sci. Polym. Chem., 47, 2219-2227 (2009) 6) Ring-Opening Metathesis Polymerization-Derived Materials for Separation Science, Heterogeneous Catalysis and Tissue Engineering, M. R. Buchmeiser, Macromol. Symp., 298, 17-24 (2010) 7) Nanoparticle-reinforced monolithic materials for application in tissue engineering, F. Weichelt, M. Drob, B. Frerich, S. Lenz, M. R. Buchmeiser, in: Biomedizinische Technik/Biomedical Engineering. Bd. 55, Heft s1, pp. 1–69, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585 
All research topics |
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Letzte Änderung 21.03.2012
( JP) | © Universität Stuttgart |
Impressum |