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 Institut für Polymerchemie

Lehrstuhl für Makromolekulare Stoffe und Faserchemie

Prof. Dr. Michael R. Buchmeiser

Inorganic Fibers for Biomedical Applications (Ca-phosphate, Hydroxylapatite)


During the last decade, biomaterials, especially bioceramics have raised a lot of interest because of their high potential as biomedical materials [1-5]. Initially only used as biocompatible media, e.g., coatings, now especially calcium orthophosphates have been intensively investigated due to their bioactive and bioresorbable nature as diverse class of biomaterials [6-8]. By controlling their structure and composition, calcium orthophosphate bioceramic grafts can be obtained, which are biologically stable or degradable once incorporated within the skeletal structure.
Furthermore, calcium phosphate fibers with adequate mechanical stability are interesting components for the development of new materials for tissue engineering and bone reconstruction. Fibrous structures of hydroxyapatite (OHAp; Ca10(PO4)6(OH)2) or tricalcium phosphate (TCP; Ca3(PO4)2) including non-woven materials can be used either as filling material or as scaffolding material in combination with a degradable CaPO4 cement [9-12]. The research project focuses on the development of calcium phosphate-based fibers with adequate mechanical properties for use in bone tissue engineering. One possibility for fabricating inorganic ceramic fibers entails the synthesis of molecular-disperse spinning dopes and producing fibrous material by pre-technical fabrication and dry- or rotation-spinning process.
For that purpose, several spinning dopes were developed and processed to non-woven green fiber materials through a rotation jet spinning process [13]. Designed thermal treatment and sintering of these leads to open porous ceramic non-woven materials composed of phase-pure Ca5(PO4)3(OH) fibers. Current investigations focus on the optimization of the mechanical properties and development of new ceramic fibers based on different CaPO4 phases.

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References:
[1] L. L. Hench, J. Am. Ceram. Soc. 1998, 81, 1705.
[2] L. L. Hench, Am. Ceram. Soc. Bull. 2005, 84, 18.
[3] S. M. Best, A. E. Porter, E. S. Thian, J. Huang, J. Eur. Ceram. Soc. 2008, 28, 1319.
[4] M. Vallet-Regí, C.R. Chimie 2010, 13, 174.
[5] G. Daculsi, O. Laboux, O. Malard, P. Weiss, J. Mater. Sc. Mater. Med. 2003, 14, 195.
[6] G. Daculsi, P. Layrolle, Key Eng. Mat. 2004, 254 - 256, 1005.
[7] S. V. Dorozhkin, Biomater. 2010, 31, 1465.
[8] S. V. Dorozhkin, J. Funct. Biomater. 2010, 1, 22.
[9] R. C. Thomson, M. J. Yaszemski, J. M. Powers, A. G. Mikos, Biomaterials 1998, 19, 1935.
[10] C. Klein, F. A. Müller, P. Greil, Key Eng. Mat. 2004, 254 -256, 391.
[11] S. Okabayashi, K. Takayama, S. Kuroda, T. Kanai, S. Fuji, M. Sato, S. Kasugai, J. Oral Tissue Engin. 2009, 6, 180.
[12] J. C. Elliot, Structure and Chemistry of the Apatites, Elsevier, 1994.
[13] M. R. Badrossamay, H. A. McIlwee, J. A. Goss, K. K. Parker, Nano Letters, 2010, 10, 6.

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Letzte Änderung 19.03.2012 (Mail to IconJP) | © Universität Stuttgart |  Impressum