Carbon catabolite degradation, a function of the proteasome
A crucial regulatory enzyme between the catabolic pathway glycolysis and the anabolic pathway gluconeogenesis is the gluconeogenic
enzyme fructose-1,6-bisphosphatase. It is rapidly degraded upon glucose addition to cells of the yeast Saccharomyces cerevisiae
growing on a non-fermentable carbon source by this preventing a futile cycle of ATP hydrolysis and allowing glycolysis to proceed.
The enzyme is degraded via the proteasome. It is an interesting example of signal induced protein degradation via this protease complex. Its investigation unravels, how an external signal finally leads to recognition of a protein and how the decision for its destruction is made.
Contact:
Prof. Dr. Dieter H. Wolf
Phone: +49-(711)-685-64390; Fax: -64392
e-mail: dieter.wolf[at]ibc.uni-stuttgart.de
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