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Institute of Biomaterials and biomolecular Systems

The Institute of Biolmaterials and biomolecular Systems comprises the departments of Bioenergetics, Biophysics, Molecular Biology and Virology of Plants, Plant Biotechnology, Animal Physiology and Biomaterials, which are integrated into the interdisciplinary concept of Technical Biology at the University of Stuttgart.
Links to the dapartments can be found on the left and at the end of this page. An overview of research topcis of the departments can be found here.


Research update:

FigureBausewein T, Mills DJ, Langer JD, Nitschke B, Nussberger S, Kühlbrandt W (2017) Cryo-EM structure of the TOM core complex from Neurospora crassa. Cell. 170: 693–700, doi: 10.1016/j.cell.2017.07.012.

The TOM complex is the main entry gate for protein precursors from the cytosol into mitochondria. The structure offers detailed insights into the molecular architecture of the mitochondrial preprotein import machinery.[more]

FigureHörmiller I, Nägele T, Augustin H, Stutz S, Weckwerth W, Heyer AG (2016) Subcellular reprogramming of metabolism during cold acclimation in Arabidopsis thaliana. Plant Cell Environ,  doi: 10.1111/pce.12836

Metabolite changes in plant leaves during exposure to low temperatures involve re-allocation of a large number of metabolites between sub-cellular compartments. To investigate these cold-induced metabolite dynamics, an integrative platform was developed that combines quantitative metabolite profiling with the non-aqueous fractionation of sub-cellular compartments. Using metabolic mutants of  Arabidopsis thaliana, this study revealed dominant effects of compartmentation on metabolite concentrations that were modulated by environmental conditions and genetic determinants. Metabolic profiles of a starchless mutant point to redox imbalance as a possible reason for reduced cold acclimation capacity. [more]

FigureDeuschle K, Kepp G, Jeske H (2016) Differential methylation of the circular DNA in geminiviral minichromosomes. Virology: 499: 243–258

Geminiviral minichromosomes were purified to explore epigenetic modifications. Levels of methylation in covalently closed circular DNA were examined with the help of methylation-dependent restriction (MdR). DNA with 12 superhelical turns was preferentially modified, indicating minichromosomes with 12 nucleosomes leaving an open gap. MdR digestion yielded a specific product of genomic length, which was cloned and sequenced, or amplified following ligation-mediated rolling circle amplification and deep-sequenced (circomics). The circomics approach identified considerably more MdR sites in a preferential distance to each other of 200 nts, which is the DNA length in a nucleosome. They accumulated in regions of nucleosome-free gaps. These results may hint at a function in specific gene regulation, as well as in virus resistance.  [more]

Departments of the Institute: